Mobile homes (MHs) are the largest source of unsubsidized affordable housing within the United States, serving as an important source of housing in Colorado for many low-income individuals and families. However, many mobile home residents are disproportionately vulnerable to the impacts of climate change, such as extreme heat and air quality hazards. This research provides an initial exploration of the physical, social, and political factors increasing heat and air quality risks in mobile homes in Colorado. Physical factors increasing climate vulnerabilities in mobile homes include substandard insulation and air temperature regulation; the social factors increasing climate vulnerabilities include a higher percentage of low-income residents and residents with pre-existing health conditions; and political factors include limits to financial assistance for mobile home residents and a lack of agency in mobile home park decision-making. However, in addition to these vulnerabilities, we also examine some of the particular strengths of mobile home residents and opportunities for policymakers that can help mitigate and adapt to these risks.