As boreal peatlands face global change, it is critical to investigate the biogeochemical controls of methane (CH4) and carbon dioxide (CO2) cycling to better understand ecosystem-climate feedbacks. Microbial reduction of redox-active organic matter (RAOM) regulates greenhouse gas production in peatlands; however, the dynamics and timescales of these processes under global change are complex and poorly understood. In a series of 3 experiments, we investigated the effects of whole ecosystem warming and elevated atmospheric CO2 concentrations on RAOM reduction and subsequent greenhouse gas production at the Spruce and Peatland Responses Under Changing Environments (SPRUCE) experiment in northern Minnesota. To measure direct effects of warming and elevated CO2, we employed ‘peat peepers’ - PVC pipes installed in the peatland that allow for equilibration between the surrounding environment and mesh packets of peat incubated through the depth profile. By installing packets filled with a common substrate, thereby controlling for peat chemistry, we found that warming, but not elevated CO2, increased RAOM reduction. However, there was no correlation between reduction and CH4 or CO2 production. We repeated the peat peeper experiment with mesh packets filled with peat from each experimental plot to include both direct warming effects and possible indirect effects like changes in peat chemistry. Unlike the first experiment, we found no differences in RAOM reduction induced by the experimental treatments, suggesting either warming effects are most pronounced in shoulder seasons or that treatments led to changes in peat chemistry that are mitigated by direct effects of warming. Finally, we investigated changes in peat chemistry by incubating peat harvested from the experimental chambers at a common temperature (18 °C) in a laboratory setting. Almost 10 years of experimental treatment neither changed the RAOM reduction nor subsequent greenhouse gas production, suggesting minimal changes in the peat chemistry regulating these processes on the decadal scale. Altogether, these results suggest peat quality and RAOM may be resilient to effects of climate change, at least after being exposed to future climate scenarios for ~10 years. This research provides insights into the uncertainties of biogeochemical processes that may alter greenhouse gas dynamics in peatland ecosystems responding to global change.